Schizophrenia beyond the brain

The Wilson Quarterly has an excellent article about the rebirth of interest in how social experiences affect the development of schizophrenia.

It’s written by the brilliant anthropologist Tanya Marie Luhrmann, who tracks how the enthusiasm for a completely neurobiological explanation for the disorder has now begun to wane.

It’s worth saying that this extreme neurobiological focus has really been an American phenomenon.

While it’s true to say that psychiatry has taken a distinct neurobiological turn across the world, the mantra that ‘schizophrenia is a brain disease’ and only needs to be understood in terms of brain function has been most strongly championed in the United States.

For somewhat mysterious reasons, and not without a touch of irony, American psychiatry has been subject to quite striking mood swings over the past century.

The ‘Freudian takeover’ only really occurred in the US, and was overturned by the diagnostic manual championing ‘mid-Atlantics’ who created the DSM-III.

Subsequently, a dominant current of thought emerged that mental illnesses could be understood as ‘brain disorders’ – a concept massively promoted and funded by drug companies. Searches for the ‘gene for schizophrenia’ and the ‘brain circuit for depression’ were all the rage, even if they seem a little naive in hindsight.

In Europe, however, social psychiatry – where mental disorders are seen within a social context – remained widely taught. In the UK, it had more an an epidemiological flavour, where on the continent it was more focussed on analysing the cultural meaning of mental illness.

Nevertheless, Luhrmann’s article is an excellent overview of how psychiatry has started to look ‘beyond the brain’, although we’d hope it doesn’t lose sight of it while gazing at the horizon

My only significant problem was that the article repeats the ‘people with schizophrenia do better in the developing world’ claim, which is so over-general as to be useless.

Other than that though, an excellent incisive article and one of the best pieces you’re likely to read in a while.

Link to ‘Beyond the Brain’ in The Wilson Quarterly (thanks Peter!)

View the original article here

A journey through schizophrenia science

BBC Radio 4's The Life Scientific recently profiled psychiatrist, schizophrenia researcher and stand-up chap, Robin Murray, who talks about how his understanding of the condition has drastically changed over the years.

It’s a fascinating journey through how our theories about the mental illness, most associated with having delusions and hallucinations, has evolved through time – taking in everything from the anti-psychiatry of R.D. Laing to modern neurogenetic studies.

As a young man, Murray lived in an Asylum in Glasgow for two years, mainly because it offered free accommodation to medical students. Struck by how people’s minds could play tricks on them and the lack of proper research into the condition, he resolved to put the study of schizophrenia on a more scientific footing. Fifteen years ago he believed schizophrenia was a brain disease. Now, he’s not so sure.

Despite decades of research, the biological basis of this often distressing condition remains elusive. Just living in a city significantly increases your risk (the bigger the city the greater the risk); and, as Murray discovered, migrants are six times more likely to develop the condition than long term residents. He’s also outspoken about the mental health risks of smoking cannabis, based both on his scientific research and direct experience working at the Maudsley Hospital in South London.

You can listen to the streamed version on the programme page but to download the podcast you have to go to a completely different page and search through the list. Why? No-one knows.

Link to page with streaming audio.
Link to podcast page.

View the original article here